弓形虫能量代谢及营养物质的来源概述

Energy Metabolism and Nutrients Sources of Toxoplasma gondii

弓形虫病是由弓形虫感染引起的严重人兽共患寄生虫病,对人类健康及畜牧业发展造成巨大威胁。弓形虫通过独特的代谢途径从宿主细胞获得营养物质进而满足其在细胞内增殖及存活。虫体自身的糖酵解及三羧酸循环途径对于其正常生长至关重要,糖酵解关键酶被抑制可促进缓殖子的形成,明确糖酵解及营养物质存储在缓殖子阶段的作用,将有助于揭示包囊形成过程中的营养需求。弓形虫嘧啶从头合成途径及生物素合成途径对于虫体存活同样不可或缺,可作为抗弓形虫药物研发的重要靶标。认识并了解弓形虫的能量代谢及营养物质的摄取方式对弓形虫病的预防和治疗发挥重要作用。

Toxoplasmosis is a severe zoonotic parasitic disease caused by Toxoplasma gondii,which has led a huge threat to human health and the development of animal husbandry.Toxoplasma gondii obtains nutrients from host cells through unique metabolic pathways to satisfy their intracellular proliferation and survival.The glycolysis and tricarboxylic acid cycle pathway are essential for its normal growth,the formation of bradyzoites will be promoted by inhibiting the key enzymes of glycolysis,it will be helpful to reveal the nutritional requirements during the formation of cysts if the role of glycolysis and nutrient storage in the bradyzoite stage were clarified.The de novo synthesis of pyrimidine and the biotin synthesis pathway are also indispensable for the survival of Toxoplasma gondii,which could be used as important targets for the development of anti-toxoplasmosis drugs.It plays an important role to know and understand the energy metabolism and nutrient ingestion of Toxoplasma gondii,which is beneficial to explore the new anti-toxoplasmosis drug targets.