铁死亡与脑卒中

Ferroptosis and stroke

背景:铁死亡作为一种与铁离子有关依赖脂质过氧化的非凋亡形式的程序性细胞死亡方式,与脑卒中的发生发展存在密切联系。目的:针对铁死亡在脑卒中的研究进展做一综述,总结铁死亡在脑卒中的发生发展中的作用及其抑制剂的应用前景,以探索脑卒中新的治疗策略,同时为靶向铁死亡治疗脑卒中提供理论依据。方法:检索PubMed、Web of Science、Medline、万方及CNKI等数据库收录的相关文献。利用Mesh检索“ferroptosis”和“stroke”完善检索词,再通过主题词(标题/摘要)进行检索。英文检索词为:“stroke;CVA;cerebrovascular accident;brain hemorrhage;brain infarction;cerebral ischemia/reperfusion injury;cerebral I/R injury;cerebral ischemia-reperfusion injury;CI/R;ferroptosis;oxytosis”;中文检索词为:“脑卒中;中风;脑出血;脑梗塞;脑缺血再灌注损伤;铁死亡”等。检索时间为2000-01-01/2020-06-25。最终纳入59篇文献进行归纳总结。结果与结论:铁死亡作为近年来新发现的一种非典型细胞死亡方式,已被证实参与脑卒中疾病的发生发展,铁螯合剂是一种经典的铁死亡抑制剂,在基础研究中显示出改善神经功能损伤的功效,但在临床试验中仍存在治疗局限性。因此,通过靶向铁死亡治疗脑卒中可能是未来研究中可进一步探索的方向。

BACKGROUND:Ferroptosis is a non-apoptotic form of programmed cell death characterized by the iron-dependent accumulation of toxic lipid reactive oxygen species,which is closely related to the occurrence and development of stroke.OBJECTIVE:To review the recent researches regarding ferroptosis in stroke and summarize the occurrence and development of ferroptosis and the application prospects of ferroptosis inhibitors in stroke,in order to provide theoretical basis and new the treatment of strategies for targeting ferroptosis in the treatment of stroke.METHODS:PubMed,Web of Science,Medline,WanFang,and CNKI databases were searched for relevant literatures.Then we used Mesh tool to search for“ferroptosis”and“stroke”to refine the search terms,and then searched by subject terms(title/abstract).Search terms were“stroke;CVA;cerebrovascular accident;brain hemorrhage;brain infarction;cerebral ischemia/reperfusion injury;cerebral I/R injury;cerebral ischemia-reperfusion injury;CI/R;ferroptosis;oxytosis”in English and Chinese,respectively.The retrieval time was from January 1,2000 to June 25,2020.Finally,59 articles were included for review.RESULTS AND CONCLUSION:Ferroptosis,as an atypical cell death mode newly discovered in recent years,has been confirmed to be involved in the occurrence and development of stroke.Iron chelator is a classic iron death inhibitor that has been shown to improve nerve function damage in basic research,but there are still some therapeutic limitations in clinical practice.Therefore,a new strategy for the treatment of stroke by targeting ferroptosis represents the direction of our future exploration.