母胎界面免疫环境与复发性流产关系的研究进展

Research progress on the relationship between maternal-fetal interface immune environment and habitual abortion

在妊娠情况下,胎儿血与母体本身血液其实并不相通,母胎界面作为胎儿与母体之间交流的界面,与胎盘屏障有相似的作用。复发性流产(RSA)是怀孕期间的常见并发症,其病因十分复杂,它通常与染色体异常、内分泌异常、免疫功能障碍和严重感染有关。近年来研究认为在病因不明的RSA患者中,多数是由于母胎界面中Th1型细胞/Th2型细胞平衡调节异常所导致。本文综述了母胎界面免疫微环境与RSA关系的研究进展。

In pregnancy,the fetal blood and the mother's blood are not actually connected.The maternal-fetal interface,as the interface between the fetus and the mother,has a similar effect to the placental barrier.Recurrent spontaneous abortion(RSA)is a common complication during pregnancy,and its etiology is very complicated,usually related to many factors,such as chromosomal abnormalities,endocrine abnormalities,immune dysfunction,and severe infections.The majority of patients with unknown RSA are caused by abnormal regulation of Th1/Th2 cell balance in the maternal-fetal interface.This article reviews the research progress on the relationship between the maternal-fetal interface immune microenvironment and RSA.