摘要
肥厚型心肌病(HCM)是最常见的遗传性心肌病之一,人群患病率为1/200。HCM患者中并发心房颤动(房颤)者约占20%。心房颤动的发生使HCM患者心脏舒张功能进一步恶化,增加了缺血性卒中/体循环栓塞的发生率,在植入心脏复律除颤器的患者中诱发更多的不合理放电,导致HCM患者心血管死亡及全因死亡事件发生的概率升高,预后明显下降。HCM患者发生心房颤动与某些临床特征或遗传异质性相关,心电图、心脏超声和磁共振等影像学相关指标可以预测心房颤动发生的风险。通过HCM患者发生心房颤动的危险因素研究,有利于早期进行危险分层、心房颤动筛查和干预,从而改善其预后和生活质量。
Hypertrophic cardiomyopathy(HCM)is one of the most common genetic cardiac disorders and has a prevalence of 1/200.Atrial fibrillation(AF)occurs in approximately 20%of HCM patients.The occurrence of AF further deteriorates the impaired diastolic function,increases the risk of ischemic stroke/systemic embolism,and induces more unreasonable discharges in patients implanted with cardioverter defibrillator,which leads to an increased probability of cardiovascular death and all-cause death events in HCM patients.Some clinical features or genetic heterogeneity are susceptible to AF in HCM patients.Indicators from electrocardiogram,cardiac ultrasound and magnetic resonance imaging can predict the risk of AF occurrence.To summarize the risk factors of atrial fibrillation in patients with HCM can facilitate the risk stratification,screening and management of AF,thus improving the prognosis and quality of life in patients with HCM.
作者
马秀英
贾锋鹏
MA Xiuying;JIA Fengpeng(Chongqing Medical University Graduate School,Chongqing 400010,China;Department of Cardiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
出处
《心血管病学进展》
CAS
2020年第12期1243-1246,共4页
Advances in Cardiovascular Diseases
关键词
肥厚型心肌病
心房颤动
危险因素
Hypertrophic cardiomyopathy
Atrial fibrillation
Risk factors
