尖锐湿疣高危自检人群HPV–DNA分型与定量检测分析

Clinical Analysis of HPV-DNA in High-risk Self-examination Population of Condyloma Acuminatum

目的:分析尖锐湿疣高危自检人群全型人乳头瘤病毒(HPV)–DNA分型与定量检测结果。方法:选取2017年10月至2019年10月于佛山市中医院进行全型HPV–DNA分型与定量检测的1980例尖锐湿疣及无症状高危自检者,利用流式荧光杂交法全分型与定量检测HPV–DNA并进行分析。结果:女性HPV–DNA阳性检出率53.48 %高于男性患者39.45 %,差异具有统计学意义(P<0.05),其中6/11型、16型、16+16/11型、18型、18+6/11型阳性检出率分别为24.19 %、6.01 %、3.94 %、3.38 %、3.33 %;不同人群HPV–DNA检测结果显示HPV–DNA阳性检出率由高至低依次为尖锐湿疣者74.02 %、尖锐湿疣病史者47.34 %、性伴侣及配偶有尖锐湿疣者43.43 %、高危性行为史自检者32.49 %、其他性病者21.38 %;HPV–DNA阳性患者患者焦虑人群占69.12 %,抑郁人群占55.65 %。结论:尖锐湿疣、无症状高危自检人群女性HPV–DNA阳性率高于男性,且以6/11型感染为主,患者均存在焦虑、抑郁症状,对于无症状高危人群应加强性病知识宣传、给予心理干预、提高HPV–DNA检测,促进患者早期接受治疗。

Objective To analyze the full human papilloma virus(HPV)-DNA typing and quantitative detection results of high-risk self-examination population of condyloma acuminata.Methods From October 2017 to October 2019,1980 patients with condyloma acuminatum and asymptomatic high-risk self-examination individuals who were subjected to HPV-DNA typing and quantitative detection at Foshan traditional Chinese medicine hospital were enrolled in the study.Flow fl uorescence hybridization was used for full typing and quantitative detection of HPV-DNA,and the results were analyzed.Results The positive detection rate of HPV-DNA in females was 53.48%,higher than 39.45%in males(P<0.05).The positive detection rates of 6/11,16,16+16/11,18,18+6/11 type were 24.19%,6.01%,3.94%,3.38%,and 3.33%.The HPV-DNA test results of different populations showed that the order of the positive detection rate of HPV-DNA from high to low was as follows:people with condyloma acuminatum(74.02%),people with history of condyloma acuminatum(47.34%),people whose sexual partners or spouses had condyloma acuminatum(43.43%),high-risk sexual history self-examination population(32.49%),and people with other sexually transmitted diseases(21.38%).In HPV-DNA positive patients,those with anxiety and depression accounted for 69.12%and 55.65%,respectively.Conclusion The positive rate of HPV-DNA is higher in females with condyloma acuminatum and asymptomatic high-risk self-examination population than in males.Besides,6/11 infection is more common.All patients have anxiety and depression.For asymptomatic high-risk population,knowledge of sexually transmitted diseases should be strengthened,psychological intervention should be carried out,and HPV-DNA testing should be improved,thus promoting early treatment of patients.