特应性皮炎与2型炎症反应

Type 2 inflammatory responses in atopic dermatitis

研究显示,2型炎症及其相关细胞因子白细胞介素4、13等在特应性皮炎(AD)中起关键作用。Th2细胞及2型细胞因子是2型炎症反应的核心驱动因素,主要通过3条路径参与AD发病:加重皮肤屏障缺陷;激活和强化瘙痒反应;调节性T细胞(Treg)病理性重编程为Th2样Treg细胞,从而放大2型炎症反应。本综述探讨2型炎症与AD的关系,希望有助于优化治疗方案,为AD患者提供新的治疗选择。

Studies have shown that the type 2 inflammatory response and related cytokines such as interleukin-4 and-13,play a key role in atopic dermatitis(AD).Th2 cells and type 2 cytokines are the core factors in the type 2 inflammatory response,which is mainly involved in the pathogenesis of AD through 3 pathways:aggravating skin barrier defects;activating and strengthening the itching response;pathologically reprograming regulatory T cells into Th2-like regulatory T cells to amplify the type 2 inflammatory response.This review explores the relationship between the type 2 inflammatory response and AD,aiming to help optimize treatment regimens and provide new treatment options for patients with AD.