第2组先天性淋巴细胞在变应性鼻炎先天性和适应性免疫应答中的作用

Effect of group 2 congenital lymphocytes in innate and adaptive immune response of allergic rhinitis

变应性鼻炎(AR)是特异性个体在环境过敏原暴露后出现鼻塞、清涕、喷嚏、鼻痒的变态反应性疾病。第2组先天性淋巴细胞(ILC2s)是先天性免疫家族新成员,通过与免疫细胞相互作参与先天性和适应性免疫反应诱导多种变应性疾病。ILC2s数量与AR的严重程度相关,可通过多种效应途径促进Th2细胞因子及IgE在鼻黏膜大量分泌介导鼻部过敏症状。本文对ILC2s的最新研究进展、参与免疫反应的机制及对AR的潜在临床效用进行综述,为临床AR防治提供思路。

Allergic rhinitis(AR)is an allergic disease in which specific individuals develop nasal congestion,clear sputum,sneezing,and itchy nose after exposure to environmental allergens.Group 2 innate lymphoid cells(ILCs)are new members of congenital immune family discovered in past 10 years,who interact with immune cells to participate in innate and adaptive immune responses,and eventually induce a variety of allergic diseases.Number of ILC2s is related to severity of AR,and ILC2s can promote secretion of Th2 cytokines and IgE in nasal mucosa through multiple effects pathways to mediate nasal allergy symptoms.This article will review the latest developments in ILC2s research,whose mechanisms involved in immune response,and potential clinical utility of AR,to provide ideas for clinical prevention and treatment of AR.