参松养心胶囊治疗非器质性室性早搏的Meta分析

Meta-analysis of Shensong Yangxin Capsules for Non-organic Ventricular Premature Beat

目的:系统分析参松养心胶囊治疗非器质性室性早搏临床有效性及安全性.方法:计算机电子检索CNKI、VIP、WanFang数据库搜集参松养心胶囊治疗非器质性室性早搏的随机对照试验(RCT),并按照纳排标准筛选文献、提取研究相关有效资料,采用RevMan5.3软件对其临床症状、心电图疗效两个指标进行Meta分析.结果:共纳入8篇随机对照试验,共计643例患者,其中参松养心胶囊组323例,对照组320例.以改善临床症状疗效为指标共纳入7篇,结果显示参松养心胶囊组在改善临床症状方面优于对照组[RR=1.32(1.13,1.55),P=0.0004].以心电图疗效为指标共纳入文献8篇,结果显示参松养心组在减少室性早搏次数方面优于对照组[RR=1.35(1.15,1.59),P=0.0003].此外,纳入的8篇文献中有5篇提到了不良反应,均可自行缓解.结论:在常规治疗基础上加用参松养心胶囊能够有效改善非器质性室性早搏患者的各项指标,值得临床推广使用.

Objective:To systematically analyze the clinical effectiveness and safety of Shensong Yangxin Capsules in the treatment of non-organic ventricular premature beats.Method:Computer electronic searched of CNKI,VIP,WanFang database to collect randomized controlled trials(RCT)of Shensong Yangxin Capsules for non-organic ventricular premature beats,screened literatures and extract relevant valid datum according to the criteria of inclusion and discharge,and used RevMan5.3 the software to analyze its clinical symptoms and ECG curative effect.Result:A total of 8 randomized controlled trials were included,which included 643 patients,including 323 cases in the Shensong Yangxin Capsules group and 320 cases in the control group.Among them,7 articles were included to improve the efficacy of clinical symptoms,the results showed that Shensong Yangxin Capsules group in improving the clinical symptoms were better than those of the control group[RR=1.32(1.13,1.55),P=0.0004].8 articles were included in the ECG curative effect as an indicator,the results showed that Shensong Yangxin Capsules group in reducing the number of ventricular premature beats were better than those of the control group[RR=1.35(1.15,1.59),P=0.0003].In addition,5 articles mentioned adverse reactions,which all resolved spontaneously.Conclusion:The addition of Shensong Yangxin Capsules on the basis of conventional treatment can effectively improve various indicators of patients with non-organic ventricular premature beats,and it is worthy of clinical application.