老年患者抗菌药源性肾损伤分析

Analysis of antimicrobial drug-induced renal injury in elderly patients

抗菌药物广泛用于老年感染患者。老年患者基础疾病多,在使用抗菌药物时需兼顾临床疗效及肾损伤情况。本文通过查阅相关文献,总结归纳抗菌药物引发肾损伤的临床机制及类型,包括间质性肾炎、肾小球损伤、肾小管损伤及结晶性肾脏病理损害,并列举常见抗菌药物诱发肾损伤机制,提出老年患者用药注意事项,旨在提高临床使用抗菌药物警惕,保证用药效率及安全,提高医疗服务水平。

Antibacterial drugs are widely used for the treatment of various types of bacterial infections in the elderly patients.It is necessary to focus on the clinical efficacy and kidney damage when using antibacterial drugs.Here we summarize the clinical mechanisms of drug-induced renal injury,we propose four phenotypes of drug-induced renal injury,including nephrolithiasis,glomerular and tubular injury and renal pathological damage.It also lists the mechanisms of common antibacterial drugs which induce kidney injury,and puts forward the precautions for medication in elderly patients.We believe that recognizing drug-induced renal injury and developing strategies to prevent adverse reactions can improve the level of medical services.