肝X受体调控抑郁障碍机制的研究进展

Research Progress in Mechanism of Liver X Receptors in Regulating Depressive Disorder

抑郁障碍是一类以情绪低落、快感缺失为主要特征的临床综合征。抑郁障碍的发病机制目前尚不明确,可能与下丘脑-垂体-肾上腺轴功能异常、单胺类递质失衡、神经发生受抑、神经炎症以及胶质细胞功能失调等有关。由于针对调控下丘脑-垂体-肾上腺轴功能和单胺类递质的临床疗效欠佳,因此,越来越多的研究关注调控神经发生、神经炎症和胶质细胞功能在抑郁障碍治疗中的作用。肝X受体(LXRs)属于核受体超家族,广泛参与脂质代谢、免疫炎症及细胞增殖的调控。LXRs在调控神经发生、神经炎症和胶质细胞功能等方面均具有重要作用,有望成为抑郁障碍新的治疗靶点。

Depressive disorder is a clinical syndrome characterized by depression and anhedonia.The specific mechanisms of depressive disorder are far from being revealed.Currently,hypothalamic-pituitary-adrenal abnormality,monoamine neurotransmitters imbalance,neurogenesis inhibition,neural inflammation,and glial cell dysfunction are associated with depressive disorder.Since the clinical therapy targeted at hypothalamic-pituitary-adrenal and monoamine neurotransmitter regulation is less effective,increasing interests are focusing on regulating neurogenesis,neural inflammation,and glial function in the clinical treatment of depressive disorder.Liver X receptors(LXRs)belong to the superfamily of nuclear receptors,which are widely involved in the regulation of lipid metabolism,immuno-inflammation,as well as cell proliferation.LXRs play a crucial role in the regulation of neurogenesis,neural inflammation,and glial function,and are expected to be a promising therapeutic target for depressive disorder.