经皮冠状动脉介入治疗发生慢血流或无复流现象的治疗进展

Treatment Progress of Slow Flow or No Reflow Phenomenon in Percutaneous Coronary Intervention

冠心病是一种最常见的心血管疾病,急性心肌梗死(AMI)是其最严重类型,及时、有效地开通梗死相关血管是AMI最重要的治疗手段。经皮冠状动脉介入治疗(PCI)作为目前最重要的再灌注手段之一,可迅速开通罪犯血管,恢复心肌血运。然而,成功进行PCI并不意味着心肌组织得到有效的血流灌注,可能出现慢血流或无复流现象,严重影响患者的预后,增加病死率。慢血流或无复流现象的发病机制十分复杂,可能与多种因素相关。目前临床上可通过药物及机械治疗预防和治疗慢血流或无复流。

Coronary heart disease is one of the most common cardiovascular diseases,and the acute myocardial infarction is the most serious type,for which timely and effective opening of infarct related vessels is the most important treatment.As one of the most important means of reperfusion at present,percutaneous coronary intervention(PCI)can quickly open the culprit vessels and restore the myocardial blood supply.However,successful PCI does not mean that the myocardial tissue is effectively perfused,because there might be slow flow or no reflow phenomenon,which seriously affects the prognosis of the patients and increases mortality.The pathogenesis of slow flow or no reflow phenomenon is very complicated,which may be related to a variety of factors.At present,drug and mechanical therapy can be used to prevent and treat slow flow or no reflow.