舒更葡糖的临床应用进展

Clinical Application progress of Sugammadex

舒更葡糖是一种经修饰的γ-环糊精,可选择性结合罗库溴铵或维库溴铵,降低在神经肌肉接头处与烟碱受体结合的非去极化肌松药物的数量,逆转罗库溴铵和维库溴铵诱导的不同程度的神经肌肉阻滞。在特殊人群的应用方面,舒更葡糖适用于儿童、老年人、肥胖者以及心血管系统、呼吸系统疾病和神经肌肉功能障碍者。舒更葡糖具有较好的耐受性和安全性,但应警惕潜在的过敏反应、出血风险和QT间期延长等。

Sugammadex is a modifiedγ-cyclodextrin,which can selectively bind rocuronium or vecuronium,reduce the number of non depolarizing muscle relaxants that bind to nicotine receptors at the neuromuscular junction,and reverse the neuromuscular block induced by rocuronium and vecuronium.As for the application on special population,it is supported to use sugammadex in children,the elderly,obese population,and population with cardiovascular system,respiratory system diseases and neuromuscular dysfunction.Sugammadex has good tolerability and safety,but we should be aware of the potential allergic reaction,bleeding risk and QT interval prolongation.