正念减压联合艾司西酞普兰治疗对焦虑症患者睡眠质量的影响

Effect of mindfulness-based stress reduction combined with escitalopram therapy on sleep quality in patients with anxiety

目的探讨正念减压(mindfulness-based stress reduction,MBSR)联合艾司西酞普兰治疗对焦虑症患者睡眠质量的影响。方法选取于2019年4月至2020年1月住院治疗的焦虑症患者(年龄≥18岁)64例,按随机数字表分为观察组(MBSR联合艾司西酞普兰组)与对照组(艾司西酞普兰组)各32例,两组患者予艾司西酞普兰片治疗,在此基础上,观察组联合MBSR,共治疗6周。比较两组患者汉密尔顿焦虑量表(HAMA)、临床总体印象量表(CGI-SI)、匹兹堡睡眠质量指数(PSQI)、抗抑郁药副反应量表(SERS)评定情况。结果第6周末,观察组HAMA总分、CGI-SI总分明显低于对照组(P<0.01);观察组的疗效优于对照组(Z=2.348,P=0.019),PSQI总分、SERS总分及药物副反应发生率均低于对照组(P<0.05或0.01)。结论正念减压联合艾司西酞普兰治疗焦虑症患者的疗效及改善患者的睡眠质量均优于单用艾司西酞普兰治疗者,药物不良反应更少,值得临床推广应用。

Objective To explore the effect of mindfulness-based stress reduction(MBSR)combined with escitalopram on sleep quality in patients with anxiety disorder.Methods A total of 64 patients with anxiety disorder(age≥18 years)who were hospitalized in our hospital from April 2019 to January 2020 were randomly divided into observation group(MBSR combined with escitalopram group)and control group(escitalopram group),with 32 cases in each group.The two groups were treated with escitalopram tablets,based on which,the observation group were combined with MBSR.Both groups were treated for 6 weeks.And then,the evaluation of Hamilton anxiety scale(HAMA),clinical global impression scale(CGI-SI),Pittsburgh sleep quality index(PSQI)and side-effect rating scale for antidepressant(SERS)were compared between the two groups.Results At the end of the 6th week,the total scores of HAMA and CGI-SI of the observation group were better than those of the control group,difference was statistically significant(P<0.01);the therapeutic effect of the observation group was better than that of the control group(Z=2.348,P=0.019),the total scores of PSQI and SERS and the incidence of adverse drug reactions in the observation group were lower than those of the control group,difference was statistically significant(P<0.05 or 0.01).Conclusion The curative effect of MBSR combined with escitalopram in the treatment of anxiety disorder and the improvement of sleep quality of patients were better than those of patients treated with escitalopram alone,with fewer adverse drug reactions,which was worthy of clinical application.