烟酰胺单核苷酸对小鼠溃疡性结肠炎的作用

Effect of NMN on DSS induced ulcerative colitis in mice

目的探究烟酰胺单核苷酸(NMN)对葡聚糖硫酸钠盐(DSS)诱导的溃疡性结肠炎小鼠模型的作用。方法采用DSS诱导溃疡性结肠炎小鼠模型评价NMN的作用。应用DSS对C57小鼠进行造模,给予NMN后观察模型小鼠的生存时间、体重、疾病评分(DAI)、结肠组织长度以及结肠组织切片病理学变化。结果NMN对模型小鼠的生存时间、体重、DAI、肠道形态学变化等无显著性改变。结论NMN对DSS诱导的溃疡性结肠炎小鼠无显著作用。

Objective To investigate the effects of Nicotinamide mononucleotide(NMN)on ulcerative colitis induced by dextran sulfate sodium(DSS)in mice.Methods DSS-induced ulcerative colitis mice were used to evaluate the effects of NMN.After NMN administration,the survival time,weight,disease activity index(DAI),colon tissue length and pathological changes of colon tissue slices were observed.Results NMN did not cause significant changes in the survival time,weight,DAI,and intestinal morphology of ulcerative colitis mice.Conclusion NMN has no significant effect on DSS-induced ulcerative colitis mice.