太子神悦胶囊提取工艺研究及方法验证

Extraction Process and Method Validation of Taizi Shenyue Capsule

目的:建立适合规模生产的太子神悦胶囊处方药材提取工艺。方法:以出膏率、总黄酮含量(以葛根素计)、总多糖含量(以葡萄糖计)、葛根素含量、淫羊藿苷含量等为评价指标,采用正交试验法筛选最佳提取工艺。结果:通过正交试验及验证,太子参最佳工艺为A1B2C2,即料液比为8倍量,提取次数3次,提取时间3 h;葛根、淫羊藿最佳工艺为A2B3C1,即料液比为12倍量,提取次数3次,提取时间1 h。结论:太子神悦胶囊处方药材提取工艺可行。

Objective:To establish an extraction process of Taizi Shenyue Capsule,prescription medicinal materials,to make it suitable for large-scale production.Methods:The extraction rate,total flavonoid content(calculated as puerarin),total polysaccharide content(calculated as glucose),puerarin content and icariin content were taken as evaluation indicators,and the orthogonal test was used to screen the best extract process.Results:Through orthogonal experiment and verification,the optimal technology for Radix Pseudostellariae was A1 B2 C2,that is,the ratio of material to liquid was 8 times,the number of extractions was 3 times,and the extraction time was 3 hours;the best extraction technology for Pueraria lobata and Epimedium was A2 B3 C1,that is,the material-liquid ratio was 12 times,the number of extraction was 3 times,and the extraction time was 1 hour.Conclusion:The extraction technology for Taizi Shenyue Capsule is feasible.