强志组方治疗抽动障碍合并反复呼吸道感染临床研究

Clinical Study on Qiangzhi Zufang Treating Tic Disorder with Recurrent Respiratory Tract Infection

目的:研究强志组方治疗儿童抽动障碍合并反复呼吸道感染症的疗效及作用机制。方法:选取2018年6月—2019年12月在山东省中医院门诊就诊的抽动障碍合并反复呼吸道感染患儿,采取自身对照的方法,每日给予中药强志组方口服,呼吸道感染急性期继予强志组方加减口服。疗程1年,治疗结束6个月后,记录治疗前及治疗后患儿呼吸道感染总次数、呼吸道感染病程、耶鲁量表评分变化,记录安全性指标以及相关不良反应。结果:治疗后患儿呼吸道感染次数、平均病程较治疗前均有减少,耶鲁评分较治疗前降低,差异有统计学意义(P<0.05)。治疗结束6个月后反复呼吸道感染总有效率87.69%(57/65),抽动障碍总有效率90.77%(59/65)。结论:强志组方治疗儿童抽动障碍合并反复呼吸道感染安全有效,临床治疗抽动障碍同时也减轻患儿反复呼吸道感染,调谐志意可以提高人体对外界环境变化的适应能力,从而增强患儿体质。

Objective:To observe the therapeutic effect and mechanism of Qiangzhi Zufang in the treatment of tic disorder and recurrent respiratory tract infection in children.Methods:65 cases of tic disorder with recurrent respiratory tract infection that met the inclusion criteria were included in the study.The children patients were treated with Qiangzhi Zufang daily.Modified Qiangzhi Zufang were applied in the acute stage of respiratory infection.The course of treatment was one year,and the patients were followed up for six months after the treatment.The total number and course of respiratory tract infection and the YGTSS score before and after the treatment were recorded.Safety indexes and related adverse reactions were recorded.Results:After the treatment,the number of respiratory tract infections and the average course of disease were decreased,and Yale score was lower compared to those before the treatment,the differences were statistically significant(P<0.05).Six months after the treatment,the total effective rate of repeated respiratory tract infection was 87.69%(57/65)%,and the total effective rate of tic disorder was 90.77%(59/65).Conclusion:Qiangzhi Zufang is safe and effective in the treatment of children’s tic disorder with recurrent respiratory tract infection,"Qiangzhi"therapy can improve the adaptability of human body to the changes of external environment,so as to enhance the physique of the children.