青海省成人大骨节病患者血清新碟呤检测结果分析

Analysis of serum neopterin level in adults patients with Kashin-Beck disease in Qinghai Province

目的了解青海省成人大骨节病(KBD)患者血清新碟呤(NPT)水平变化。方法2018年7月在青海省海南藏族自治州兴海、贵德县KBD病区,依据《大骨节病诊断》(WS/T 207-2010),选取确诊的20岁以上成人KBD患者及健康人群分别作为KBD组和病区内对照组;同时,在生产、生活方式相似的非病区循化县选取20岁以上健康人群作为病区外对照组。采集3组人群空腹肘静脉血,采用酶联免疫吸附试验(ELISA)法检测血清NPT水平。结果共调查272人,其中KBD组104人(男性50人、女性54人),年龄为(47.61±12.72)岁;病区内对照组95人(男性35人、女性60人),年龄为(48.28±14.87)岁;病区外对照组73人(男性35人、女性38人),年龄为(51.88±13.93)岁。3组间性别构成、年龄比较,差异均无统计学意义(χ^2=3.135,F=2.236,P均>0.05)。KBD、病区内对照、病区外对照组血清NPT水平分别为(504.35±413.92)、(417.34±109.90)、(397.49±118.07)ng/L,组间比较差异有统计学意义(F=4.129,P<0.05)。其中,KBD组血清NPT水平显著高于病区内、外对照组(P均<0.05);病区内、外对照组血清NPT水平比较,差异无统计学意义(P>0.05)。结论青海省成人KBD患者血清NPT水平升高。

Objective To investigate the changes of serum neopterin(NPT)level in adults patients with Kashin-Beck disease(KBD)in Qinghai Province.Methods In July 2018,according to the"Diagnosis of Kashin-Beck Disease"(WS/T 207-2010),in KBD endemic region of Xinghai and Guide counties in Hainan Tibetan Autonomous Prefecture of Qinghai Province,adult KBD patients and healthy people over 20 years old were selected as KBD group and internal control group,respectively.At the same time,healthy people over 20 years old were selected as the external control group in non-KBD endemic region of Xunhua County with similar production scale and lifestyle.Fasting elbow vein blood samples of the 3 groups of people were collected,serum NPT levels were determined by enzyme linked immunosorbent assay(ELISA).Results Totally 272 people were enrolled in the study,104 cases(50 males and 54 females)in KBD group,aged(47.61±12.72)years old;95 cases(35 males and 60 females)in internal control group,aged(48.28±14.87)years old;and 73 cases(35 males and 38 females)in external control group,aged(51.88±13.93)years old.There were no significant differences in gender composition and age among the 3 groups(χ^2=3.135,F=2.236,P>0.05).The serum NPT levels of KBD,internal control,and external control groups were(504.35±413.92),(417.34±109.90)and(397.49±118.07)ng/L,respectively,and the difference among the 3 groups was statistically significant(F=4.129,P<0.05).Among them,the serum NPT level of KBD group was significantly higher than that of internal control group and external control group(P<0.05);there was no significant difference in the serum NPT level between internal control group and external control group(P>0.05).Conclusion The serum NPT level of adult KBD patients in Qinghai Province is elevated.