阿托伐他汀治疗脑梗死患者颈动脉粥样硬化斑块的效果

Effect of atorvastatin on carotid atherosclerotic plaque in patients with cerebral infarction

目的探究阿托伐他汀治疗脑梗死患者颈动脉粥样硬化斑块的临床疗效。方法选取2016年7月至2018年7月本院收治的60例脑梗死患者为研究对象,随机分为两组,实验组32例,对照组28例。两组均给予常规方法治疗,实验组在此基础上给予阿托伐他汀药物治疗,观察两组治疗前后血脂指标变化、颈动脉粥样硬化斑块面积及厚度。结果治疗前,两组患者TC、TG、LDL、HDL值比较差异无统计学意义;经3个月治疗后,两组TC、TG、LDL水平均降低,HDL水平升高,且实验组TC、TG、LDL低于对照组,HDL高于对照组,差异均具有统计学意义(P<0.05);治疗前,两组斑块面积及斑块厚度比较差异无统计学意义;治疗后,两组斑块面积及斑块厚度均降低,实验组低于对照组,差异具有统计学意义(P<0.05)。结论阿托伐他汀治疗颈动脉粥样硬化斑块脑梗死患者,能有效改善颈动脉粥样硬化斑块状态,增强斑块稳定性,能有效控制病情,降低病死率。

Objective To investigate the clinical efficacy of atorvastatin in the treatment of carotid atherosclerotic plaque in patients with cerebral infarction.Methods 60 patients with cerebral infarction in our hospital from July 2016 to July 2018 were randomly divided into two groups.32 patients were included in the experimental group,and 28 patients were included in the control group.Both groups were treated with conventional methods,the experimental group was given atorvastatin drug treatment on this basis.The the changes of blood lipid index and carotid atherosclerotic plaque area and thickness were observed before and after treatment.Results Before treatment,there were no significant differences in TC,TG,LDL,and HDL between the two groups.After 3 months of treatment,the TC,TG and LDL values were decreased in two groups,the HDL value were increased,the TC,TG,LDL in the experimental group were lower than that in the control group,the HDL in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in plaque area and plaque thickness between the two groups before treatment.After treatment,the plaque area and plaque thickness of the two groups were decreased,the experimental group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion Atorvastatin can improve the carotid atherosclerotic plaque in patients with carotid atherosclerotic plaque cerebral infarction,and the plaque stability is greatly enhanced,which effectively controls the disease and reduces the mortality rate.