早年创伤与精神分裂症症状的相关性

Correlation between childhood trauma and schizophrenia symptoms

目的·探索早年创伤的不同维度与精神分裂症阳性和阴性症状的相关性。方法·在上海市精神卫生中心招募124例精神分裂症患者,采用早年创伤问卷简表(Early Trauma Inventory Short Form,ETI-SF)评估早年创伤情况,采用阳性和阴性症状量表(Positive and Negative Syndrome Scale,PANSS)评估精神症状。采用Pearson相关分析及高斯图模型网络分析方法,将早年创伤的4个维度分别与PANSS的3个亚量表及30个条目评分进行相关性分析。结果·控制年龄、性别等影响因素后,早年创伤中躯体虐待(r=0.29,P=0.000)和情感虐待(r=0.21,P=0.024)与精神分裂症阳性症状存在显著的相关性。各个维度的创伤均与阳性症状不同子条目存在相关关系;网络分析也验证了躯体虐待和情感虐待与精神分裂症阳性症状存在较强的相关性;在整个网络图中回避社交节点的网络度中心性值最大。结论·早年创伤与精神分裂症阳性症状关系密切,其中躯体虐待与阳性症状显著相关,主动回避社交在整个网络中起重要的中介作用。

Objective·To explore the relationship between different dimensions of childhood trauma and positive and negative symptoms of schizophrenia.Methods·A total of 124 patients with schizophrenia were recruited at Shanghai Mental Health Center.Childhood trauma was evaluated by the Early Trauma Inventory Short Form(ETI-SF),and psychotic symptoms were evaluated by the Positive and Negative Syndrome Scale(PANSS).Pearson correlation analysis and Gaussian graphical model(GGM)were used to examine the relationship between 4 dimensions of ETI-SF and the scores of 3 subscales or total 30 items of PANSS.Results·There was a significant correlation between subscales of positive symptoms and physical abuse(r=0.29,P=0.000)or emotional abuse(r=0.21,P=0.024)after controlling age,sex and other confounding factors.All dimensions of ETI-SF were related to different items of positive symptom scale.GGM results also verified that physical and emotional abuse were strongly correlated with the positive symptoms in schizophrenia.In addition,the degree centrality value of active social avoidance was the biggest through the whole network.Conclusion·Childhood trauma is related to positive symptoms of schizophrenia.Physical abuse and emotional abuse are significantly related to the positive symptoms.Active social avoidance plays an important role in the whole network.