摘要
虽然已发现双相障碍(bipolar disorder,BD)患者存在明显的情感、认知环路相关的大脑结构与功能改变,但其特异性神经影像学机制到目前为止尚无定论,其中一个原因可能是不同亚型BD导致的样本异质性。双相障碍Ⅰ型(bipolarⅠdisorder,BD-Ⅰ)是BD中发病率最高、症状最典型的亚型之一,集中对BD-Ⅰ患者的研究或许更能揭示BD的疾病机制,探索有效的治疗方案。该文就近5年来BD-Ⅰ相关的磁共振成像研究进行综述,以期了解目前BD的神经影像学研究进展,并探索潜在的研究方向。
The brain structural and functional impairment in affective and cognitive circuits has been detected in bipolar disorder(BD)patients;however the specific neuroimaging mechanism of BD is still inconsistent.One of the reasons may be the sample heterogeneity caused by subtypes of BD.BipolarⅠdisorder(BD-Ⅰ)is one of the BD types with the highest prevalence and the most typical symptoms.It may be better to reveal the mechanism of BD and explore targeted treatment through research focusing on BD-Ⅰpatients.This article reviews the magnetic resonance imaging(MRI)studies about BD-Ⅰin recent 5 years to better know about advances in this field and explore the potential research directions.
作者
杨涛
陈俊
方贻儒
YANG Tao;CHEN Jun;FANG Yi-ru(Clinical Research Center,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2020年第12期1660-1664,共5页
Journal of Shanghai Jiao tong University:Medical Science
基金
国家重点研发计划(2016YFC1307100)
国家自然科学基金(91232719,81761128032)
深圳市“医疗卫生三名工程”(SZSM201612006)。
关键词
双相障碍Ⅰ型
磁共振成像
结构
功能
bipolarⅠdisorder(BD-Ⅰ)
magnetic resonance imaging(MRI)
structure
function
