老年食管癌调强放疗效果及预后影响分析

Effect And Prognostic Impact Of Intensity-Modulated Radiotherapy In Elderly Patients With Oesophageal Cancer

目的观察老年食管癌调强放疗(IMRT)效果及预后影响。方法回顾性分析兴化市第三人民医院2013年1月至2015年3月收治的100名接受调强放疗治疗的食管癌患者的临床资料,对其临床治疗效果以及相关预后因素进行分析。结果患者中急性放射性肺炎不良反应Ⅰ级、Ⅱ级、Ⅲ级发生率分别为4.00%、1.00%、1.00%,急性放射性食管炎不良反应Ⅰ级、Ⅱ级、Ⅲ级发生率分别为36.00%、15.00%、2.00%,骨髓抑制不良反应Ⅰ级、Ⅱ级、Ⅲ级发生率分别为30.00%、14.00%、3.00%,消化道不良反应Ⅰ级、Ⅱ级、Ⅲ级发生率分别为13.00%、3.00%、1.00%;所有老年食管癌患者的中位生存时间为(19.53±3.53)个月,1、2、3、5年生存率分别为67.00%、49.00%、28.00%及9.00%。病变部位,肿瘤轮廓(GTV)以及联合化疗均为老年食管癌患者调强放射治疗生存时间影响的独立因素。结论调强放疗治疗老年食管癌患者,既安全又有效。

Objective To observe the effect of intensity-modulated radiotherapy(IMRT)on the prognosis of elderly patients with esophageal cancer.Methods The clinical data of 100 patients with oesophageal cancer treated with intensity-modulated radiotherapy from January 2013 to March 2015 at Xinghua Third People's Hospital retrospectively reviewed,and their clinical treatment effcacy as well as related prognostic factors were analysed.Results Among patients,the incidences of grade Ⅰ,Ⅱ,and Ⅲ adverse reactions in acute radiation pneumonitis were 4.00%,1.00%,1.00%,respectively,and those of grade Ⅰ,Ⅱ,and Ⅲ adverse reactions in acute radiation esophagitis were 36.00%,15.00%,2.00%,respectively,and those of grade Ⅰ,Ⅱ,and Ⅲ adverse reactions in myelosuppression were 30.00%,14.00%,3.00%,respectively,gastrointestinal adverse reactionsⅠ,Ⅱ,Ⅲincidence were 13.00%,3.00%and 1.00%respectively;the median survival time of all elderly patients with esophageal cancer was(19.53±3.53)months,and the 1,2,3,and 5-year survival rates were 67.00%,49.00%,28.00%,and 9.00%,respectively.Lesion location,GTV,as well as combined chemotherapy were all independent factors for the survival time effect of IMRT in elderly patients with esophageal cancer.Conclusion IMRT is safe and effective for elderly patients with esophageal cancer.