阿立哌唑与利培酮早期干预对精神分裂症患者认知功能的影响

Effect of Early Intervention with Aripiprazole and Risperidone on Cognitive Function in Patients with Schizophrenia

目的对比分析阿立哌唑与利培酮早期干预精神分裂症的临床效果,以及对患者认知功能的影响。方法选取北京市昌平区中西医结合医院2017年8月至2019年1月收治的精神分裂症患者80例作为研究对象,患者早期均接受封闭式隔离管理,按照不同的用药方案分为利培酮组(30例)与阿立哌唑组(50例)。比较两组患者的认知功能筛查量表(MOCA)、阳性与阴性症状量表(PANSS)、汉密尔顿抑郁量表(HAMD)、日常生活能力(ADL)评分及不良反应发生率。结果治疗后,阿立哌唑组患者的MOCA、PANSS评分、HAMD、ADL评分及不良反应发生率与利培酮组比较,差异均有统计学意义(P<0.05)。结论在对于患有精神分裂症和(或)伴有情绪相关症状的治疗中,采用阿立哌唑进行早期干预,对改善患者的认知功能、焦虑及抑郁情绪、稳定心境,以及减少日后出现精神障碍的结局均比利培酮治疗效果更优,值得临床推广应用。

Objective Comparative analysis of aripiprazole and risperidone in early intervention of schizophrenia,as well as the impact on the patient's cognitive function.Methods A total of 80 schizophrenic patients admitted to Changping District Hospital of Integrated Traditional Chinese and Western Medicine from August 2017 to January 2019 were selected as the research objects.All the patients received closed isolation management in the early stage,and were divided into risperidone group(n=30)and aripiprazole group(n=50)according to different drug regimen.MOCA,PANSS,HAMD,ADL scores and the incidence of adverse reactions were compared between the two groups.Results MOCA score,PANSS score,HAMD score,ADL score and adverse reaction rate of aripiprazole group patients after treatment were significantly different from risperidone group(P<0.05).Conclusion In the treatment of patients with schizophrenia and/or mood related symptoms,aripiprazole for early intervention is more effective than peridone in improving patients'cognitive function,anxiety and depression,stabilizing mood,and reducing the outcome of later mental disorders,which is worthy of clinical promotion and application.