肝硬化终末期患者的治疗和管理

Treatment and management of patients with end-stage liver cirrhosis

肝硬化终末期通常指肝硬化失代偿期所致的慢性肝衰竭,为人类健康带来沉重负担。肝移植是最为有效的治疗,但受肝源缺乏、费用高昂等因素的严重限制。人工肝往往作为桥接治疗。细胞治疗的发展为其带来新的希望。探讨了肝硬化终末期病因治疗及并发症的管理,介绍了肝硬化终末期进行人工肝、细胞治疗、肝移植的适应证和时机。

End-stage liver cirrhosis usually refers to chronic liver failure caused by decompensated liver cirrhosis and brings a heavy burden to human health.Liver transplantation is the most effective treatment,but its clinical application is limited by the shortage of liver source and high cost.Artificial liver support system is often used as bridging therapy to liver transplantation.The development of cell therapy brings new hope to this disease.This article summarizes the etiological treatment of end-stage liver cirrhosis and the management of related complications and introduces the indications and timing for artificial liver support system,cell therapy,and liver transplantation in patients with end-stage liver cirrhosis.