新型冠状病毒肺炎合并肝损伤的发生机制

Pathogenesis of coronavirus disease 2019 with liver injury

新型冠状病毒肺炎已对全球公共卫生造成了重大威胁。除呼吸系统外,部分患者可出现不同程度的肝损伤。基于相关文献,对病原学特征及其致病机制进行分析,初步探讨导致新型冠状病毒肺炎合并肝损伤出现的原因可能有病毒的直接作用、炎性细胞因子风暴、药物性肝损伤、低氧性肝损伤及免疫功能障碍等。建议临床可选择合理药物进行护肝治疗,减少肝损伤的发生。

Coronavirus disease 2019(COVID-19)has become a major threat to global public health.In addition to injury in the respiratory system,some patients may have varying degrees of liver injury.With reference to related articles,this article analyzes the etiological characteristics and pathogenesis of COVID-19 and discusses the possible causes of COVID-19 with liver injury,including the direct effect of virus,inflammatory cytokine storm,drug-induced liver injury,hypoxic liver injury,and immune dysfunction.It is suggested that reasonable drugs should be selected in clinical practice to protect the liver and reduce the incidence rate of liver injury.