参榆洗剂联合曲安奈德益康唑乳膏治疗足癣的疗效观察

Clinical Observation on Erosive Interdigital Tinea Pedis Treated by Shenyu Solution Combined with Triamcinolone Acetonide and Econazole Nitrate Cream

【目的】观察参榆洗剂联合曲安奈德益康唑乳膏治疗浸渍糜烂型足癣的临床疗效。【方法】将64例浸渍糜烂型足癣患者随机分为治疗组和对照组,每组各32例。对照组给予曲安奈德益康唑乳膏外涂治疗,治疗组给予参榆洗剂浸泡联合曲安奈德益康唑乳膏外涂治疗,疗程为4周,并于疗程结束后4周进行随访。观察2组患者治疗前后临床症状总积分的变化情况,比较2组患者的病原清除情况和复发情况,评价2组患者的临床疗效和安全性。【结果】(1)治疗过程中,对照组脱落2例,治疗组无脱落病例,最终对照组30例、治疗组32例完成试验。(2)治疗4周后,治疗组的愈显率和总有效率分别为78.1%(25/32)和96.9%(31/32),对照组分别为56.7%(17/30)和90.0%(27/30);2组患者的总有效率比较,差异无统计学意义(P>0.05),但治疗组的愈显率和总体疗效均优于对照组,差异均有统计学意义(P<0.05)。(3)治疗后,2组患者的临床症状总积分均较治疗前明显降低(P<0.05),且治疗组的降低作用明显优于对照组,差异有统计学意义(P<0.05)。(4)治疗后,治疗组和对照组的病原清除率分别为90.6%(29/32)、86.7%(26/30),组间比较,差异无统计学意义(P>0.05)。(5)在疗程结束后4周,治疗组的复发率为9.4%(3/32),对照组为16.7%(5/30),组间比较,差异无统计学意义(P>0.05)。(6)治疗过程中,2组患者均无明显的不良事件发生。【结论】参榆洗剂联合曲安奈德益康唑乳膏治疗浸渍糜烂型足癣疗效确切,其疗效优于单纯使用曲安奈德益康唑乳膏治疗。

Objective To investigate the clinical efficacy of Shenyu Solution combined with Triamcinolone Acetonide and Econazole Nitrate Cream for the treatment of erosive interdigital tinea pedis. Methods Sixty-four patients diagnosed as erosive interdigital tinea pedis were randomly divided into treatment group and control group,and each group had 32 cases. The control group was given external application of Triamcinolone Acetonide and Econazole Nitrate Cream,while the treatment group was given soaking the affected feet with Shenyu Solution together with external application of Triamcinolone Acetonide and Econazole Nitrate. The treatment for the two groups lasted 4 weeks. The follow-up was carried out 4 weeks after the completion of treatment. Before and after treatment, the scores of clinical symptoms in the two groups were observed. The pathogen clearance and the recurrence as well as the clinical efficacy and safety in the two groups were compared. Results(1)During the treatment, 2 cases from the control group dropped out while none case from the treatment group dropped out.And at the end of the trial,30 cases of the control group and 32 cases of the treatment group completed the trial.(2)After treatment for 4 weeks,the markedly effective and curative rate and the total effective rate of the treatment group were 78.1%(25/32)and 96.9%(31/32)respectively,and were 56.7%(17/30)and 90.0%(27/30)in the control group respectively. The intergroup comparison showed that the difference of the total effective rate between the two groups was not statistically significant(P>0.05),but the markedly effective and curative rate and the overall efficacy in the treatment group were superior to those in the control group,the difference being statistically significant(P < 0.05).(3)After treatment, the total scores of clinical symptoms in the two groups were markedly decreased in comparison with those before treatment(P<0.05), and the decrease of the total scores in the treatment group was superior to that in the control group,the difference being statistically significant(P < 0.05).(4)After treatment,the pathogen clearance rate in the treatment group and the control group was 90.6%(29/32)and 86.7%(26/30)respectively,and the intergroup comparison showed that the difference between the two groups was not statistically significant(P>0.05).(5)Four weeks after the completion of treatment,the recurrence rate in the treatment group was 9.4%(3/32)and that in the control group was 16.7%(5/30),and the intergroup comparison showed that the difference between the two groups was not statistically significant(P>0.05).(6)During the trial,no adverse event occurred in the two groups. Conclusion Soaking the affected feet with Shenyu Solution together with external application of Triamcinolone Acetonide and Econazole Nitrate exerts certain effect for the treatment of erosive interdigital tinea pedis, and its effect is stronger than that of the external application of Triamcinolone Acetonide and Econazole Nitrate alone.