上海市嘉定区居民甲状腺疾病与心血管疾病及相关危险因素的相关性研究

Correlation of thyroid disease with cardiovascular disease and its related risk factors among residents in Jiading District,Shanghai Municipality

目的探讨甲状腺疾病与心血管疾病及相关危险因素的相关性。方法利用上海市公共卫生与预防医学"高峰计划"学科建设中健康人群队列项目数据,采用问卷调查和生化指标了解人群的基本情况、慢性病病史及相关生化指标分布。结果本次共调查10051人,892人(8.87%)患有甲状腺疾病,女性患病率(12.18%)高于男性(3.91%)(P=0.000)。被诊断为患有高血压、糖尿病及发生过脑卒中患者与未患有该类疾病患者其甲状腺疾病患病情况均无差异(9.15%vs.8.71%、9.20%vs.8.84%、10.73%vs.8.77%)(P均>0.05);高脂血症患者甲状腺疾病患病率(11.79%)高于未患有高血脂者(8.38%),冠心病患者甲状腺疾病患病率(14.46%)高于未患有冠心病者(8.54%)(P<0.05)。女性甲状腺疾病患者其高脂血症、冠心病及脑卒中患病率均明显高于未患有这三种疾病者(16.89%vs.11.44%、20.53%vs.11.68%、16.18%vs.11.94%)(P均<0.05),以上指标在男性中均无差异。甲状腺疾病患者的LDL-C、HDL-C及TC水平均高于未患有该病者[(2.75±0.84)mmol/L vs.(2.63±0.81)mmol/L、(1.42±0.33)mmol/L vs.(1.36±0.33)mmol/L、(5.00±0.95)mmol/L vs.(4.84±0.91)mmol/L,P均<0.001]。结论甲状腺疾病与心血管疾病及其危险因素之间存在相关,对于有心血管疾病或有相关危险因素者,尤其是患甲状腺疾病女性,应密切监测其甲状腺功能,积极预防心血管病的发生。

Objective To explore the relationship of thyroid disease with cardiovascular disease and its related risk factors.Methods We used the data about the healthy population cohort project in the subject construction of the"Peak Program"of Public Health and Preventive Medicine in Shanghai Municipality.Questionnaire survey and biochemical index examination were conducted to investigate the subjects’general information,history of chronic diseases and distribution of related biochemical indexes.Results A total of 10,051 subjects were surveyed.892(8.87%)subjects had thyroid disease,and the prevalence rate of the disease was higher in females than in males(12.18%vs.3.91%,P=0.000).No statistically significant differences were found in the prevalence rate of thyroid disease between patients diagnosed with and without hypertension,diabetes and stroke(9.15%vs.8.71%,9.20%vs.8.84%,10.73%vs.8.77%;all P>0.05).The prevalence rate of thyroid disease was higher in patients with hyperlipidemia than in patients without hyperlipidemia(11.79%vs.8.38%)as well as higher in patients with coronary heart disease than in patients without coronary heart disease(14.46%vs.8.54%,P<0.05).The prevalence rates of hyperlipidemia,coronary heart disease and stroke were significantly higher in women with thyroid disease than in women without the three diseases(16.89%vs.11.44%,20.53%vs.11.68%,16.18%vs.11.94%;P<0.05),but no statistically significant differences were observed in the above-mentioned indexes in men.Patients with thyroid disease had higher levels of low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)and total cholesterol(TC)than those without the disease((2.75±0.84)mmol/L vs.(2.63±0.81)mmol/L,(1.42±0.33)mmol/L vs.(1.36±0.33)mmol/L,(5.00±0.95)mmol/L vs.(4.84±0.91)mmol/L;all P<0.05).Conclusions Thyroid disease is associated with cardiovascular disease and its risk factors.As for people with cardiovascular disease or its related risk factors,especially women with thyroid disease,thyroid function should be closely monitored to actively prevent the occurrence of cardiovascular disease.