慢性阻塞性肺疾病急性加重期患者PA、Hcy和hs-CRP水平与病情预后的相关性研究

Correlation between PA,Hcy and hs-CRP levels and prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者前清蛋白(PA)、半胱氨酸(Hcy)和超敏-C反应蛋白(hs-CRP)水平与病情预后的相关性。方法选取2018年2月至2019年9月在该院接受治疗的AECOPD患者120例为观察组,选取同期该院体检健康者120例为对照组,比较两组PA、Hcy、hs-CRP水平和肺功能指标情况。根据AECOPD患者的预后分为好转组95例和加重组25例,比较两组PA、Hcy、hs-CRP水平和肺功能指标情况,并分析AECOPD患者PA、Hcy和hs-CRP水平与肺功能指标的相关性。结果观察组PA、Hcy、hs-CRP水平高于对照组,用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、最大呼气中期流量(MMEF)和最大呼气流量(PEF)低于对照组,差异均有统计学意义(P<0.05);加重组PA、Hcy、hs-CRP水平高于好转组,FVC、FEV1、MMEF和PEF低于好转组,差异均有统计学意义(P<0.05);AECOPD患者的PA、Hcy、hs-CRP水平与FVC、FEV1、MMEF、PEF均呈负相关(P<0.05)。结论AECOPD患者的PA、Hcy和hs-CRP水平较高,且与患者的预后密切相关,可为患者预后治疗提供参考。

Objective To investigate the correlation between the levels of prealbumin(PA),cysteine(Hcy),high sensitivity C-reactive protein(hs-CRP)and prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 120 AECOPD patients who were treated in our hospital from February 2018 to September 2019 were selected as the observation group,and 120 healthy people in the same period were selected as the control group.The levels of PA,Hcy,hs-CRP and pulmonary function indexes of the two groups were compared.According to the prognosis of AECOPD patients,they were divided into improvement group(95 cases)and addition group(25 cases).PA,Hcy,hs-CRP levels and pulmonary function indexes were compared between the two groups,and the correlation between PA,Hcy,hs-CRP levels and pulmonary function indexes were analyzed.Results The levels of PA,Hcy and hs-CRP in the observation group were higher than those in the control group,forced vital capacity(FVC),forced expiratory volume(FEV1),maximum mid expiratory flow(MMEF)and maximum expiratory flow(PEF)were lower than those in the control group,the differences were statistically significant(P<0.05);the levels of PA,Hcy and hs-CRP in the observation group were higher than those in the improvement group,the FVC,FEV1,MMEF and PEF in the observation group were lower than those in the improvement group(P<0.05).The levels of PA,Hcy and hs-CRP in AECOPD patients were negatively correlated with FVC,FEV1,MMEF and PEF(P<0.05).Conclusion The levels of PA,Hcy and hs CRP in patients with AECOPD are higher,which are closely related to the prognosis of patients,which can provide reference for the prognosis and treatment of patients.