摘要
前列腺癌是最常见的男性恶性肿瘤之一,早期不易诊断,常伴有远端转移,预后极差。上皮间质转化是肿瘤细胞发生侵袭、转移的重要因素,非编码RNA能以多种方式参与调控前列腺癌的上皮间质转化,从而影响前列腺癌的发生、发展和恶性转移。该文主要对3类非编码RNA调控前列腺癌上皮间质转化的机制作一综述,旨在对其进行深刻阐述与总结,并为寻找高效的前列腺癌治疗靶标提供一定参考。
Prostate cancer is one of the most common male malignant tumors.It is characterized by difficult early diagnosis,distant metastasis,and poor prognosis.Epithelial-mesenchymal transformation is mportant for the invasion and metastasis of tumor cells.Non-coding RNA can regulate the process of prostate cancer in many ways,thus affecting its occurrence,development and malignant metastasis.This article mainly reviews the mechanisms of three types of non-coding RNA in regulating the process of prostate cancer,in order to elaborate and summarize them,and to provide some reference for finding efficient therapeutic targets for metastatic prostate cancer.
作者
尹冶
丁明霞
陈振杰(综述)
王玉明(审校)
YIN Ye;DING Mingxia;CHEN Zhenjie;WANG Yuming(Department of Clinical Laboratory,the Second Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650000,China;Department of Urology Surgery,the Second Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650000,China)
出处
《国际检验医学杂志》
CAS
2021年第1期116-121,共6页
International Journal of Laboratory Medicine
基金
云南省基础研究计划项目(2019FE001-226)
云南省科技人才和平台计划项目(2019IC034)。
