经皮微创接骨板内固定术对肱骨干中段骨折患者关节功能及血清BGP、PICP、CTX水平的影响

Effects of percutaneous minimally invasive bone plate internal fixation on joint function and serum BGP,PICP,CTX levels in patients with mid-shaft fracture of the humerus

目的分析经皮微创接骨板内固定术对肱骨干中段骨折患者关节功能及血清骨钙素(BGP)、Ⅰ型原胶原羟基端延长肽(PICP)、胶原羧基末端肽(CTX)水平的影响。方法选取2018年3月至2019年11月武安市第一人民医院收治的肱骨干中段骨折患者90例,采用随机数字表法分为对照组(45例)与观察组(45例)。对照组患者行传统切开复位内固定术,观察组患者行经皮微创接骨板内固定术,两组患者均于术后随访6个月。比较两组患者手术情况;比较两组患者术前、术后6个月关节功能及血清BGP、PICP、CTX水平;比较两组患者术后6个月并发症发生情况。结果与对照组比,观察组患者手术时间、住院时间、骨折愈合时间均缩短,且术中出血量减少;与术前比,术后6个月两组患者Mayo评分与Constant Murley评分及血清BGP、PICP水平均升高,且观察组高于对照组;而血清CTX水平均降低,且观察组低于对照组;术后6个月观察组患者并发症总发生率(4.44%)低于对照组(22.22%)(均P<0.05)。结论经皮微创接骨板内固定术可提升肱骨干中段骨折患者治疗效果,改善关节功能,进而促进骨折愈合,并减少并发症。

Objective To analyze the effects of percutaneous minimally invasive bone plate internal fixation on joint function and serum levels of bone gla protein(BGP),propeptide of typeprocollagen(PICP)and collagen carboxy-terminal peptide(CTX)in patients with mid-shaft fracture of the humerus.Methods A total of 90 patients with mid-shaft fracture of the humerus admitted to the WU'AN First People's Hospital from March 2018 to November 2019 were selected and divided into the control group(45 cases)and the observation group(45 cases)according to the random number table rule.Patients in the control group underwent traditional open reduction and internal fixation,and patients in the observation group underwent percutaneous minimally invasive bone plate internal fixation.ALL patients were followed up for 6 months after surgery.The surgical conditions were compared between the two groups;the joint function and serum BGP,PICP,CTX levels were compared between the two groups before and 6 months after surgery;the incidence of complications were compared betwwen the two groups at 6 months after surgery.Results Compared with the control group,the operation time,hospital stay and fracture healing time of the observation group were shortened,and the intraoperative blood loss was reduced;compared with preoperatively,the Mayo score,Constant Murley score,serum BGP and PICP levels of the two groups of patients increased 6 months after surgery,and the observation group was higher than the control group;while the serum CTX level was decreased,and the observation group was lower than the control group;the total incidence of complications in the observation group(4.44%)was lower than that of the control group(22.22%)6 months after surgery(all P<0.05).Conclusion Percutaneous minimally invasive bone plate internal fixation can improve the treatment effects of patients with mid-shaft fracture of the humerus,improve joint function,promote fracture healing and reduce complications.