维生素A、E、D水平与儿童生长激素缺乏症的相关性研究

Correlation between vitamin A,E and D levels and growth hormone deficiency in children

目的探讨血清维生素A、E及25-羟维生素D[25-(OH)D]水平与儿童生长激素缺乏症(GHD)的相关性。方法选取2015年1月至2019年11月在该院儿科确诊为GHD的80例患儿作为研究组(GHD组),同期70例健康儿童作为对照组。比较两组血清维生素A、维生素E、25-(OH)D及胰岛素样生长因子-1(IGF-1)水平的差异。结果GHD组血清维生素A、25-(OH)D、IGF-1水平均明显低于对照组(Z=-5.098、-8.915、-10.563,P<0.001);血清维生素A、25-(OH)D水平与IGF-1水平呈正相关关系(r=0.304、0.550,P<0.001),血清维生素E水平与IGF-1水平无相关性(r=0.597,P=0.597);GHD组农村患儿维生素A水平显著低于城市患儿(Z=-4.302,P<0.001),而维生素E、25-(OH)D、IGF-1水平无区域差别(P>0.05)。结论GHD患儿血清维生素A、25-(OH)D明显降低且与IGF-1水平呈正相关。

Objective To investigate the relationship between growth hormone deficiency(GHD)and serum vitamin A,E and 25-(OH)D levels in children.Methods A total of 80 children diagnosed with GHD in the department from January 2015 to November 2019 were selected as the study group(the GHD group),and 70 healthy children were selected as the control group.The levels of serum vitamin A,E,25-(OH)D and insulin-like growth factor-1(IGF-1)were compared between the two groups.Results The levels of vitamin A,25(OH)D in the GHD group were significantly lower than those in the control group(Z=-5.098,-8.915,-10.563,P<0.001).Vitamin A,25-(OH)D was positively correlated with IGF-1(r=0.304,0.550,P<0.001).Serum levels of vitamin E has no relevance with IGF-1 level(r=0.597,P=0.597).Vitamin A level in rural children was significantly lower than that in urban children(Z=-4.302,P<0.001).And vitamin E,25-(OH)D,IGF-1 level no regional difference(P>0.05)Conclusion The serum levels of vitamin A,25-(OH)D and IGF-1 in GHD were all significantly decreased which were positively correlated with IGF-1 levels in GHD.