卡铂注射液致过敏性休克一例及文献复习

One case of anaphylactic shock induced by carboplatin injection and literature review

目的针对1例病例探讨卡铂注射液如何引起过敏性休克及发生事件后的应对措施。方法通过病例及文献搜索分析发生过敏性休克事件的各种相关性,找出应对不良反应的解决方法。结果考虑病例由卡铂注射液引起过敏性休克的可能性更大,不建议使用顺铂代替,建议患者的后续治疗停用铂类药物。结论卡铂过敏反应多数发生在输注开始后数分钟,患者化疗到7个疗程后需要予以监测,防止出现严重的过敏性休克事件。

Objective Discussion a case on carboplatin injection how to cause anaphylactic shock and solutions after the incident.Methods To analyze the correlation of anaphylactic shock by the case process and searching the literature,and finding a solution to an adverse reaction.Results Considering the possibility of the case anaphylactic shock caused by carboplatin injection.Not recommended to replace it with cisplatin.It is suggested that patients should stop using platinum chemotherapy drugs during subsequent treatment.Conclusion Allergic reactions to carboplatin mostly occur within minutes of the start of the infusion.Patients need to be monitored after 7 courses of chemotherapy to prevent severe anaphylactic shock.