基于失连接理论:关键位置纤维微结构损伤在脑小血管病相关认知功能障碍发病机制中的研究进展

Strategic white matter microstructure damage can lead to cognitive impairment in cerebral small vessel disease:disconnection syndrome

脑小血管病(CSVD)是老年人认知功能障碍最常见的血管病因,病变症状映射研究发现关键位置白质纤维微结构的损伤可能是CSVD相关认知功能障碍潜在的发病机制,即皮层-皮层或皮层-皮层下失连接综合征。弥散张量成像(DTI)为白质微结构损伤的研究提供了无创的纤维追踪方法,故本文就DTI研究中失连接综合征在CSVD相关认知功能障碍中的研究及关键位置纤维微结构损伤与不同认知域的相关性作一综述。

Cerebral small vessel disease(CSVD)is the most common vascular cause of cognitive impairment in the elderly.The lesion-symptom mapping studies found that the damage of strategically located white matter microstructure may be the potential pathogenesis of CSVD-related cognitive impairment,namely cortical-cortical or cortical-subcortical disconnection syndrome.Diffusion tensor imaging(DTI)provides a non-invasive fiber tracking method for the study of white matter microstructure damage.Therefore,this article reviews the study of disconnection syndrome in CSVD-related cognitive impairment and the correlation between fiber microstructure damage and different cognitive domain dysfunction in DTI studies.