自噬影响卵巢癌细胞休眠的相关机制研究进展

Research Progress on the Mechanism of Autophagy Affecting Ovarian Cancer Cell Dormancy

休眠现象在哺乳动物细胞中广泛存在,是细胞的一种稳定且主动的抑制状态。休眠状态的细胞代谢活性降低、转录和翻译受到抑制、抑癌基因表达增加、DNA损伤减少、存在G0和GAlert两个阶段,化学药物、炎症等均可能影响细胞的休眠。在正常干细胞中,休眠有助于维持组织的动态平衡,对机体有一定的保护作用。而在肿瘤中,休眠却可以帮助细胞逃避免疫监视,适应环境,抵抗药物,恢复恶性增殖能力,并为肿瘤复发做准备。化疗耐药以及肿瘤复发是卵巢癌预后极差的重要原因。近年来研究发现,休眠与卵巢癌耐药和复发密切相关。该文旨在探讨卵巢癌细胞休眠特征,从细胞自噬入手,串联肿瘤血管生成、细胞周期和耐药之间的相互关系,为卵巢癌的复发、转移、治疗和预防等研究提供新思路。

Dormancy is widespread in mammalian cells,and is a stable and active state of inhibition of cells.The cellular metabolic activity in the dormant state is reduced,and transcription and translation are inhibited.Tumor suppressor gene expression is increased,while DNA damage is reduced.There are two stages of G0 and GAlert,and chemical drugs and inflammation may affect cell dormancy.In normal stem cells,dormancy helps maintain the dynamic balance of tissues and has a certain protective effect on the body.In tumors,dormancy can help cells escape immune surveillance,adapt to the environment,resist drugs,restore malignant proliferation,and prepare for tumor recurrence.Chemotherapy resistance and tumor recurrence are important reasons for the extremely poor prognosis of ovarian cancer.In recent years,studies have found that dormancy is closely related to drug resistance and recurrence of ovarian cancer.This article aims to explore the dormancy characteristics of ovarian cancer cells.Starting from autophagy,this article links the relationship among tumor angiogenesis,cell cycle and drug resistance,providing new ideas for the research of ovarian cancer recurrence,metastasis,treatment and prevention.