REG蛋白在胰腺恶性肿瘤中的研究进展

Research Progress of REG Protein in Pancreatic Cancer

胰腺癌是临床常见的消化道恶性肿瘤之一。因其早期多无特异性临床表现,往往发现时已成晚期,难以进行手术治疗,同时,化学治疗的疗效常常不佳,故其病死率较高。REG基因编码的REG蛋白属于小分泌蛋白家族,在炎症时分泌增多,具有调节细胞生长和凋亡的能力,与胰腺恶性肿瘤的关系密切。探究REG蛋白与胰腺恶性肿瘤的关系对了解胰腺恶性肿瘤的发生发展;制定诊断与治疗方案以及判断预后的意义重大。

PC (pancreatic cancer) is an common digestive cancer.When diagnosed,the stage of PC is late due to little specific symptom.Meanwhile,surgery can hardly be performed on late-stage PC patients and the efficacy of chemotherapy barely meets the satisfaction.The mortality of PC is high.REG protein coded by REG gene belongs to small secretory protein family.The level of REG protein will increase,when body has inflammation.REG protein can also alter the tumor cell proliferation and anti-apoptosis.The relation between REG protein and PC is close.Understanding the association between REG protein and PC will have a crucial meaning to oncogenesis,diagnosis,treatment and prognosis of PC.