昼夜钟调节细胞衰老的研究进展

Research Progress of Circadian Clock Involved in Cellular Senescence

昼夜钟是普遍存在于哺乳动物下丘脑视交叉上核和外周组织的内源性调节系统,使生物体的生理活动和行为以地球自转24 h为周期发生昼夜改变。除了调控组织发育和多种疾病的发生外,昼夜钟还可通过影响细胞周期、细胞内活性氧水平等方式参与细胞衰老的调控。该文综述了昼夜钟参与细胞衰老调控的作用机制,并总结了其参与调控的细胞衰老信号通路,有助于从多角度研究细胞衰老的机制。

Circadian clock is an endogenous regulatory system commonly found in the mammalian suprachiasmatic nucleus of hypothalamus and peripheral tissues,which makes the physiological activities and behaviors of organisms carry out the day-and-night cycle with the rotation of the earth for 24 h.In addition to regulating tissue development and the occurrence of diseases,circadian clock can also regulate cellular senescence by affecting cell cycle,intracellular reactive oxygen species and so on.In this paper,the mechanism of circadian clock involved in regulating cellular senescence is reviewed,and the cellular senescence-associated signaling pathways regulated by circadian clock are summarized to help to study the mechanism of cellular senescence in various aspects.