低分子肝素联合苯扎贝特治疗高脂血症胰腺炎临床效果观察

Observation of clinical effect of low molecular weight heparin combined with Bezafibrate in treatment of hyperlipidemia pancreatitis

目的探讨低分子肝素联合苯扎贝特治疗高脂血症胰腺炎的临床效果。方法选择2018年1月-2020年4月宜春市第二人民医院收诊的54例高脂血症胰腺炎患者,采用随机数字表法分为A组(18例)、B组(18例)、C组(18例)。A组采用常规治疗,B组采用常规治疗+苯扎贝特治疗,C组采用常规治疗+苯扎贝特+低分子肝素治疗。比较3组患者临床相关指标、胃肠功能恢复时间、住院时间及急性生理学及慢性健康状况评分系统Ⅱ(APACHEⅡ)评分。结果治疗3 d、5 d、7 d后,C组白细胞计数(WBC)、甘油三酯、血淀粉酶、超敏C反应蛋白(hs-CRP)水平及APACHEⅡ评分均比A组、B组低,且B组比A组低,差异有统计学意义(P<0.05);C组胃肠功能恢复时间、住院时间均比A组、B组短,且B组比A组短,差异有统计学意义(P<0.05)。结论低分子肝素联合苯扎贝特可减轻高脂血症胰腺炎患者炎症反应,降低血脂,缩短胃肠功能恢复时间及住院时间,改善预后。

Objective To explore the clinical effect of low molecular weight heparin combined with bezafibrate on hyperlipidemia pancreatitis.Methods A total of 54 patients with hyperlipidemia pancreatitis admitted in our hospital from January2018 to April 2020 were selected and divided into group A(18 cases),group B(18 cases),and group C(18 cases) according to random number table method.Group A received conventional treatment,group B received conventional treatment+bezafibrate,and group C received conventional treatment+bezafibrate+low molecular weight heparin.Compared the clinically relevant indexes,recovery time of gastrointestinal function,hospitalization time,acute physiology and chronic health status scoring system Ⅱ(APACHE Ⅱ) scores of the three groups of patients.Results After 3 days,5 days,and 7 days of treatment,the white blood cell count(WBC),triglyceride,blood amylase,high-sensitivity C-reactive protein(hs-CRP) levels and APACHE Ⅱ scores of group C were lower than those of groups A and B,and group B was lower than group A,the difference was statistically significant(P<0.05);gastrointestinal function recovery time and hospitalization time of group C were shorter than that of group A and group B,and group B was shorter than group A,the difference was statistically significant(P<0.05).Conclusion Low molecular weight heparin combined with bezafibrate can reduce inflammatory response,reduce blood lipids,etc.in patients with hyperlipidemia pancreatitis,shorten their recovery time of gastrointestinal function and their hospital stay,and improve prognosis.