摘要
Constitutively expression of the pathway-specific activators is an effective method to activate silent gene clusters and improve natural product production.In this study,nine shunt products of aminoansamycins(1-9)were identified from a recombinant mutant strain S35-LAL by overexpressed the large-ATP-binding regulator of the LuxR family(LAL)gene aas1 in Streptomyces sp.S35.All the compounds showed no anti-microbial,anti-T3 SS and cytotoxic activities.
基金
supported by the National Natural Science Foundation of China(Nos.81673317,81530091,and31570039)
the Open Funding Project of State Key Laboratory of Microbial Metabolite Funding(No.MMLKF17-09)
the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R68)。
