IL-41/Metrnl的生物学特性及在代谢与炎症相关疾病中的作用

Biological Characteristics of IL-41/Metrnl and Its Role in Metabolism and Inflammation-related Diseases

白细胞介素(interleukin,IL)-41是一种新近发现和重新命名的细胞因子或脂肪因子.IL-41也曾分别被称为Metrnl、Cometin、Subfatin、Meteorin(Metrn)-like或Meteorin-β、IL-39等.IL-41/Metrnl是一种小分子分泌蛋白,在体内广泛表达,特别是在皮肤、黏膜和白色脂肪组织中高表达.它在神经发育、白色脂肪褐变、胰岛素敏感、代谢与炎症相关疾病中起重要作用.IL-41/Metrnl的功能和作用机制有待进一步证实.本文将综述IL-41/Metrnl的生物学特性、表达及其在代谢与炎症相关疾病中的作用研究进展,为研究相关疾病的治疗靶点或药物提供新思路.

Interleukin(IL)-41 is a newly discovered and renamed cytokine or adipokine.IL-41 has also been called Metrnl,Cometin,Subfatin,Meteorin(metrn)-like or Meteorin-β,and IL-39,respectively.IL-41/Metrnl is a small secretory protein,which is widely expressed in vivo,especially in skin,mucosa and white adipose tissue.It plays an important role in neurodevelopment,white adipose browning,insulin sensitization,metabolism and inflammation-related diseases.The function and mechanism of IL-41/Metrnl need to be further confirmed.This paper reviews the biological characteristics,expression,and role of IL-41/Metrnl in metabolism and inflammation-related diseases,and provides new ideas for the research of therapeutic targets or drugs of related diseases.