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养血固肾汤对绝经后骨质疏松症患者骨代谢指标、骨密度的影响 被引量:7

Effect of Yangxue Gushen Decoction on Bone Metabolism Index and Bone Mineral Density in Postmenopausal Osteoporosis Patients
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摘要 目的观察养血固肾汤对绝经后骨质疏松症患者骨代谢指标、骨密度的影响。方法选取2017年6月—2019年5月收治的绝经后骨质疏松症患者80例,按照随机数字表法分为对照组(40例)和观察组(40例)。对照组给予口服碳酸钙+骨化三醇胶丸的基础治疗,观察组在对照组基础上服用养血固肾汤。观察2组治疗前后血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平、骨代谢指标及骨密度的变化。结果治疗前2组血清IL-6、TNF-α、甲状旁腺激素(PTH)、降钙素(CT)和骨钙素(BGP)水平及骨密度值的差异无统计学意义(P>0.05),治疗后2组血清IL-6、TNF-α水平均降低,且观察组降低更多,差异有统计学意义(P<0.05);治疗后2组BGP、CT和PTH水平及骨密度值均高于治疗前,且观察组升高更多,差异有统计学意义(P<0.05)。结论养血固肾汤能降低绝经后骨质疏松症患者血清IL-6、TNF-α水平,提高血清BGP、CT和PTH水平及骨密度值,临床适合用于绝经后骨质疏松症患者的治疗。 Objective To observe the effect of Yangxue Gushen decoction on bone metabolism index and bone mineral density in postmenopausal patients with osteoporosis.Methods From June 2017 to May 2019,80 patients with postmenopausal osteoporosis were enrolled in our hospital.The patients were divided into the control group(40 cases)and the observation group(40 cases)according to the random number table method.The control group was given basic treatment of calcium carbonate and calcitriol capsules,and the observation group took Yangxue Gushen decoction on the basis of the control group.The changes of serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)levels,bone metabolic markers and bone mineral density were observed before and after treatment.Results There were no significant differences in serum IL-6,TNF-α,parathyroid hormone(PTH),calcitonin(CT)and osteocalcin(BGP)levels and bone mineral density between the two groups before treatment(P>0.05).After treatment,serum IL-6 and TNF-αlevels decreased,and the observation group decreased more,and the difference was statistically significant(P<0.05).BGP,CT and PTH levels and bone mineral density after treatment were higher than before treatment,the observation group increased more,and the difference was statistically significant(P<0.05).Conclusion Yangxue Gushen decoction can reduce serum IL-6 and TNF-αlevels in postmenopausal osteoporosis patients,improve serum BGP,CT and PTH levels and bone mineral density,and is suitable for postmenopausal osteoporosis patients.
作者 程毅 江共涛 胡和军 魏星星 徐南云 CHENG Yi;JIANG Gongtao;HU Hejun;WEI Xingxing;XU Nanyun(Department of Orthopaedics,Nanchang Hongdu Hospital of Traditional Chinese Medicine,Jiangxi Province,Nanchang 330000,China)
出处 《中国中医药现代远程教育》 2020年第24期80-82,共3页 Chinese Medicine Modern Distance Education of China
基金 江西省卫生计生委中医药科研课题项目【No.2018A157】。
关键词 绝经 骨质疏松症 养血固肾汤 骨代谢指标 骨密度 中医药疗法 menopause osteoporosis Yangxue Gushen decoction bone metabolism index bone density therapy of traditional Chinese medicine
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