固相合成法制备单官能度纳米粒子

Fabrication of Mono-Functional Nanoparticles Based on a Solid-Phase Platform

以巯基严格稀疏修饰的硅球为基底结合固相合成法高效制备了确定单官能度的纳米粒子。通过透射电镜(TEM)对四臂树枝状聚苯乙烯(FDP)在固相基底硅球表面的接枝和解离进行可视化跟踪,发现接枝到硅球表面的FDP均相对独立分布;将FDP中用于“占位”的聚苯乙烯嵌段解离后,接枝点留下在硅球表面严格稀疏分布的巯基。同样,通过TEM对单官能度金纳米粒子的固相合成过程及其“单价态”进行表征,结果表明:成功通过固相合成法制备了确定单官能度的金纳米粒子;金纳米粒子表面的活性官能团之间能高效反应成金纳米粒子二聚体;单官能度纳米粒子可作为组装单元构筑结构可控的纳米粒子组装体。

Herein,the fabrication of nanoparticles(NPs)with exact one functional group on the surface was reported.Mono-functional NPs were prepared by solid phase synthesis based on the strict sparse modification of silica sphere substrate.Four-arm dendrimer-like polystyrene(FDP)was employed to grafted onto the surface of the silica spheres and occupy a certain area on the surface,the FDP was confirmed to distribute independently on the surface by TEM.As a result,the thiol groups exposed at the graft point on the surface of silica sphere were strictly sparsely distributed after dissociating the polystyrene arms of the FDP.One-by-one attachment of AuNPs sized smaller than the diameter of the FDP and then cleaved the linker between silica sphere and AuNPs endowed the AuNPs with exact one reactive group.Mono-valence of the AuNPs were confirmed by dimerization between them.A high yield of AuNPs dimers demonstrated the relatively high reactivity of the surface functional group.The mono-functional AuNPs are strong candidates for constructing nanoparticle assemblies with controlled structure.