3-溴-5-乙炔基苯甲酸的合成

Synthesis of 3-Bromo-5-ethynylbenzoic Acid

本文以3,5-二溴苯甲酸为原料,通过酯化反应、Sonogashira反应、酯水解及脱保护反应,得到3-溴代-5-乙炔基苯甲酸,各步反应的收率分别是94.7%、69.3%、94.8%。

3-Bromo-5-ethynylbenzoic acid was prepared by esterification reaction, Sonogashira coupling reaction, ester decomposition and deprotection used 3,5-dibromobenzoic acid as starting material. The yields of the three steps were 94.7%, 69.3% and 94.8%, respectively.