摘要
目的测定普乐沙福的波谱学特征,确证其化学结构。方法利用红外光谱(IR)、紫外光谱(UV)、核磁共振(NMR)、高分辨质谱(MS)、热分析和X-射线粉末衍射(XRD)等技术对普乐沙福进行结构分析。结果通过解析证实普乐沙福的结构为1,1’-[1,4-亚苯基(亚甲基)]-二-1,4,8,11-四氮杂环十四烷。结论该方法准确可行,可为普乐沙福的质量控制和结构鉴定提供依据。
Objective To determine the spectroscopic characteristics and to identify the chemical structure of plerixafor with a variety of analytic techniques.Methods The infrared spectrometry,ultraviolet-visible spectrometry,nuclear magnetic resonance,mass spectrometry,thermal analysis and X-ray powder diffraction were adopted to analyze the chemical structure of plerixafor.Results The chemical structure of plerixafor was determined to be 1,1’-[1,4-phenylenebis (methylene)]bis-1,4,8,11-tetraazacyclotetradecane.Conclusion The method is accurate and reliable,and it can provide a reference for the production control and identification of plerixafor.
作者
江任之
梁平
王玲
程红
曾甜甜
严定策
JIANG Ren-zhi;LIANG Ping;WANG Ling;CHENG Hong;ZENG Tian-tian;YAN Ding-ce(Analytical and Testing Center,Huazhong University of Science and Technology,Wuhan 430074)
出处
《中南药学》
CAS
2021年第1期50-55,共6页
Central South Pharmacy