利奈唑胺群体药动学的文献分析

Research progress of linezolid in population pharmacokinetics

利奈唑胺是临床常用的抗革兰氏阳性菌感染药物,其个体间药动学差异大。本文通过查阅当前发表的利奈唑胺群体药动学文献,提取建模相关信息并进行分析归纳与综述,以期为利奈唑胺的临床用药提供参考。相关文献表明利奈唑胺代谢的主要影响因素为体重、年龄、肌酐清除率和肾小球滤过率,临床制订给药方案时应优先考虑这些因素。

Linezolid is a commonly used anti gram-positive bacterial infection drug,with different pharmacokinetics.In this paper,currently published literatures about population pharmacokinetic of linezolid were reviewed,and the information related to the modeling was extracted,analyzed and summarized to provide reference for the use of linezolid.The main influencing factors of linezolid metabolism were body weight,age,creatinine clearance rate and glomerular filtration rate.These factors should be considered in the optimization of clinical dosing regimen.