叔丁基N-{3-[(2-氨基乙基)氨基]丙基}氨基甲酸酯合成研究

Synthesis of Tert-butyl N-{3-[(2-aminoethyl)Amino]Propyl}Carbamate

以廉价的2-溴乙胺氢溴酸盐为起始原料,经过Cbz胺基保护,氨基亲核取代反应及催化氢化得到目标化合物(叔丁基N-{3-[(2-氨基乙基)氨基]丙基}氨基甲酸酯。探索了反应温度、反应时间、反应熔剂、投料比等因素对关键步骤氨基亲核取代的影响,优化了反应条件及分离方法,三步总收率为85.6%。为该类脂肪胺的合成提供了一条高效的合成方法。

Using cheap 2-bromoethylamine hydrobromide as the starting material,the target compound(tert-butyl N-{3-[(2-amino group)is obtained through Cbz amine group protection,nucleophilic amino substitution reaction and catalytic hydrogenation.Ethyl)amino]propyl)carbamate.The effects of factors such as reaction temperature,reaction time,reaction flux,and feed ratio on the nucleophilic substitution of amino groups in the key steps were explored.The reaction conditions and separation methods were optimized,and the three-step total yield The rate is 85.6%,which provides an efficient synthesis method for the synthesis of fatty amines.