mTOR信号通路在细胞自噬和凋亡调节中的作用

Role of mTOR signaling pathway in the regulation of autophagy and apoptosis

自噬及凋亡广泛存在于细胞中,是细胞内生物大分子的降解再循环过程,在细胞生长代谢中发挥着重要作用。两者相互作用,共同推动和影响细胞的程序性死亡,维持机体自身稳态及外界环境刺激下的应激反应。mTOR信号通路是一条经典的调控自噬凋亡信号通路,在细胞代谢中发挥重要作用。结合mTOR信号通路探讨自噬及凋亡在细胞代谢及生物体生长发育过程中的作用及相关研究进展,对其在细胞增殖、老化及肿瘤发生等进行综述,对肿瘤等疾病的诊疗提供借鉴。

Autophagy and apoptosis widely exist in cells,which are the degradation and recycling process of biomolecules in cell and play an important role in cell growth and metabolism.Their interaction jointly promote and influence the programmed death of cells,and maintain the self-stability of body and stress response under external environmental stimulation.The mTOR signaling pathway is one of classical signaling pathway of regulating autophagy-apoptosis that plays an important role in cell metabolism.This paper combined with mTOR signaling pathway and related research progress.It mainly discussed the role and relevant research progress of autophagy and apoptosis in cell metabolism and organism growth-development,and reviewed the autophagy and apoptosis in cell growth,development,aging and tumor formation.This will provide a positive reference in the diagnosis and treatment of tumor and other diseases.