血清铁蛋白和甲胎蛋白联合检测原发性肝癌的诊断分析

Diagnostic value of combined detection of serum ferritin and alpha fetoprotein in primary liver cancer

目的探讨血清铁蛋白和甲胎蛋白联合检测原发性肝癌的诊断效果。方法选取2018年1月至2019年5月本院收治的原发性肝癌患者72例,并选取肝硬化患者80例,健康体检者80名为研究对象,检测并分析3组血清铁蛋白和甲胎蛋白水平。结果肝癌组血清铁蛋白和甲胎蛋白水平明显高于肝硬化组与对照组,且肝硬化组明显高于对照组,差异均有统计学意义(P<0.05);血清铁蛋白和甲胎蛋白联合应用的ROC曲线下面积为0.835,诊断特异度为84.66%,灵敏度为90.41%,优于单一指标。结论血清铁蛋白和甲胎蛋白联合检测可取得较好的原发性肝癌诊断价值,值得临床推广应用。

Objective To investigate the diagnostic effect of serum ferritin and alpha fetoprotein in primary liver cancer.Methods From January 2018 to may 2019,72 cases of primary liver cancer,80 cases of liver cirrhosis and 80 cases of healthy people were selected as the research subjects.The levels of serum ferritin and alpha fetoprotein among three groups were detected and analyzed.Results The levels of serum ferritin and alpha fetoprotein in liver cancer group were significantly higher than those in cirrhosis group and control group,and the difference was statistically significant(P<0.05);the area under ROC curve of combined application of serum ferritin and alpha fetoprotein was 0.835,the diagnostic specificity was 84.66%,and the sensitivity was 90.41%,which were better than single index.Conclusion Combined detection of serum ferritin and alpha fetoprotein can obtain good diagnostic value of primary liver cancer,which is worthy of clinical application.