盐酸多巴酚丁胺注射液与左西孟旦治疗缺血性心肌病心力衰竭的疗效和心功能及预后比较

Comparison of the efficacy,cardiac function and prognosis of dobutamine hydrochloride injection and levosimendan in the treatment of heart failure in ischemic cardiomyopathy

目的比较盐酸多巴酚丁胺注射液与左西孟旦治疗缺血性心肌病心力衰竭的临床疗效及对心功能与预后的改善效果。方法选取2017年4月至2019年4月本院收治的缺血性心肌病心力衰竭患者80例为研究对象,按照随机数字表法分为两组,各40例。对照组采取盐酸多巴酚丁胺注射液治疗,观察组采取左西孟旦治疗,比较两组临床疗效及心功能改善情况。结果观察组总有效率为92.5%,高于对照组的75.0%(P<0.05);治疗后,观察组CI、LVEF指数高于对照组,LVEDD、BNP水平低于对照组,差异有统计学意义(P<0.05)。结论左西孟旦治疗缺血性心肌病心力衰竭临床疗效优于盐酸多巴酚丁胺注射液,更有利于患者改善心功能及预后,值得临床推广应用。

Objective To compare the clinical efficacy of dobutamine hydrochloride injection and levosimendan in the treatment of heart failure in ischemic cardiomyopathy with the improvement of cardiac function and prognosis.Methods 80 patients with ischemic cardiomyopathy and heart failure admitted to our hospital from April 2017 to April 2019 were selected as the research subjects,and they were divided into two groups according to the random number table method,with 40 cases in each group.The control group was treated with dobutamine hydrochloride injection and the observation group was treated with levosimendan.The clinical efficacy and improvement of cardiac function between the two groups were compared.Results The total effective rate was 92.5%in the observation group,which was higher than 75.0%in the control group(P<0.05).After treatment,CI,LVEF and LVEDD indexes in the observation group were higher than the control group,and BNP level was lower than the control group,the difference was statistically significant(P<0.05).Conclusion Levosimendan is superior to dobutamine hydrochloride injection in the treatment of heart failure in ischemic cardiomyopathy,and is more beneficial to the improvement of cardiac function and prognosis in patients,which is worthy of clinical application.