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监测血清降钙素原对骨折手术感染抗菌药物应用影响分析

Effect of monitoring serum procalcitonin on the use of antibiotics in surgical infection of fracture
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摘要 目的探讨监测血清降钙素原对骨折手术感染抗菌药物应用影响。方法选取2017年1月至2019年1月本院收治的100例骨折手术感染患者为研究对象,采用随机数字表法分为两组,每组50例。对照组采用抗菌药物治疗,观察组采用抗菌药物联合监测血清降钙素原治疗,比较两组治疗前后细胞因子水平、抗菌药物使用时间与住院时间。结果治疗后,两组血清降钙素原(PCT)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05);观察组抗菌药物使用、住院时间均短于对照组,差异均有统计学意义(P<0.05)。结论监测血清降钙素原有利于合理调整感染抗菌药物应用,可有效改善患者PCT、IL-6、TNF-α、CRP水平,缩短抗菌药物使用时间、住院时间,值得临床推广应用。
作者 管婉如 GUAN Wanru
出处 《当代医学》 2021年第4期121-122,共2页 Contemporary Medicine
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