吸烟、白细胞计数与男性放射工作人员血清胆红素水平的关联性

Analysis of the correlation between smoking,white blood cell counts and serum bilirubin levels in male radiation workers

目的分析吸烟、白细胞计数与男性放射工作人员血清胆红素水平的关联性,探讨机体炎症反应在吸烟对血清胆红素水平影响中的作用机制。方法基于某医疗机构对1320名男性放射工作人员在岗或离岗时的职业健康检查数据,利用线性回归分析方法分别分析吸烟与白细胞计数、吸烟与血清胆红素水平、白细胞计数与血清胆红素水平之间的关联性。结果吸烟与白细胞计数呈显著正相关(P<0.05),同时吸烟、白细胞计数均与血清胆红素水平呈显著负相关(P<0.05)。校正白细胞计数后,吸烟与血清胆红素水平的关联无统计学意义(P>0.05)。通过对白细胞二分位分组,吸烟与血清胆红素水平的关联性仅在高白细胞计数组中具有统计学意义(P<0.05)。结论血清胆红素可能是吸烟致男性放射工作人员早期健康损害的效应指标;在吸烟引起的炎症反应中,胆红素可能被消耗而导致其水平下降。

Objective To investigate the correlation between smoking,white blood cell counts,and serum bilirubin levels in male radiation workers,and to explore the role of systemic inflammatory response in the changes of serum bilirubin levels induced by smoking.Methods Occupational health examination data of 1320 male radiation workers in a medical institution was collected.Linear regression analysis method was used to analyze the correlations between smoking and white blood cell counts,between smoking and serum bilirubin levels,and between white blood cell counts and serum bilirubin levels.Results There was a significant positive correlation between smoking and white blood cell counts(P<0.05).Both smoking and white blood cell counts were significantly negatively correlated with serum bilirubin levels(P<0.05).However,after adjusting the white blood cell counts,the correlation between smoking and serum bilirubin levels was not statistically significant(P>0.05).By dividing white blood cell counts into two groups,an inverse correlation was found between smoking and serum bilirubin levels in the high white blood cell count group(P<0.05).Conclusion Serum bilirubin may be an effective indicator of early health damage caused by smoking in male radiation workers.Smoking may induce inflammatory reaction,thus deplete serum bilirubin and cause its levels to drop.