顺铂耳毒性机制及耳保护策略研究进展

Progress in Research on Protection Strategies against and Mechanisms of Cisplatin Ototoxicity

顺铂作为抗癌一线用药,多用于卵巢癌、前列腺癌、睾丸癌、肺癌、甲状腺癌等癌症的治疗,具有较强的广谱抗癌作用,也常伴有一些副作用,如肾毒性、耳毒性、骨髓抑制等。顺铂的耳毒性可导致双侧永久性听力损失,这会使患者的生活质量受到极大影响,特别是在言语交流和社会发展方面。因此,在应用顺铂治疗癌症的同时,也应注意加强对其耳毒性的防护。目前对顺铂的耳毒性防护,主要集中在应用抗氧化药物、减少细胞摄取和开发新型铂配合物等方面。现将近年来对顺铂耳毒性机制的最新研究进展和新发展的耳保护策略做一综述。

As a first line anticancer drug,cisplatin is widely used in the treatment of oophoroma,prostate carcinoma,testicular carcinoma,lung carcinoma and thyroid carcinoma.Its broad-spectrum strong anticancer effects are often accompanied by side effects,such as nephrotoxicity,ototoxicity,myelosuppression,etc.Cisplatin ototoxicity can lead to bilateral permanent hearing loss,which can greatly affect patients’quality of life,especially in terms of verbal communication and social development.Therefore,while applying cisplatin in treatment of cancer,attention must be paid to protection against ototoxicity.At present,protection against cisplatin ototoxicity is mainly focused on use of antioxidant drugs,reduction of its cell uptake and development of new less toxic platinum complexes.In this article,we reviewed the latest research progress on the mechanism of cisplatin ototoxicity and newly developed protection strategies.